Last year Tech. One year later, Tech. Meeting founders and investors, something becomes clear: there is a slew of programs and early-stage investment opportunities here to help startups and founders find their path. The latest addition to the pack is ByFounders. Government-supported InnoFounder is an incubator program for recent graduates. The one-year initiative provides a monthly stipend equity free for would-be entrepreneurs to develop ideas into businesses with the help of mentors and established entrepreneurs from the local Danish ecosystem. While Denmark has produced some banner companies in the likes of Zendesk and Unity for example, the local ecosystem continues to evolve and look for its next global success story.
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visited TechBBQ in Copenhagen to get a sense of where the local startup ecosystem is headed and how it will scale.
The aim of this study is to investigate whether we can verify the presence of protein pools within the same tissue with very distinct turnover rates over the life-span of rats with special focus on connective tissue. The tracers were injected during fetal development Day to -2 , after birth Day 5—9 , at weaning Day 25—32 at puberty Day 54—58 and at adulthood Day — Subgroups of rats were euthanized three days after every injection period, at different time point between injection periods and lastly at day Tissue liver, muscle, eye lens and patellar tendon and blood samples were collected after euthanization.
In contrast, the connective tissue protein in the eye lens and patellar tendon of the mature rat showed detainment of tracer enrichment injected during fetal development and first living days, indicating very slow turnover. The data support the hypothesis that some proteins synthesized during the early development and growth still exist much later in life of animals and hence has a very slow turnover rate. To allow growth and remodeling as well as functional integrity most proteins are undergoing a process of continuous turnover involving degradation of existing proteins and biosynthesis of replacement proteins.
Connective tissue and collagen protein turnover is of specific interest, since existing results on synthesis and turnover rates are conflicting.
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